RNU6-540P

Across TCGA pan-cancer cohorts, RNU6-540P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-540P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU6-540P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-540P is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

HNSC, COAD, and READ are the cancer types where RNU6-540P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-540P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.245	.028	5	view →
COAD	Female	All	−0.237	.010	4	view →
READ	All	III,IV	−0.675	.023	2	view →
PRAD	All	All	+0.259	.003	2	view →
KIRC	Male	All	+0.234	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RNU6-540P–HNSC

Open the HNSC breakdown →