RNU6-538P

Across TCGA pan-cancer cohorts, RNU6-538P RNA is linked to patient survival in 6 of 34 cancer types, making it the most broadly survival-associated RNU6-538P data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher RNU6-538P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNU6-538P expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

LUSC, KIRC, and ACC are the cancer types where RNU6-538P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	III,IV	0.079	0.658	<.001	63	view →
KIRC	OS	Tertile	II,III,IV	0.168	0.696	.021	54	view →
ACC	OS	Tertile	All	0.133	0.686	.004	54	view →
STAD	OS	Tertile	All	0.247	0.735	.001	36	view →
LAML	DFS	Tertile	All	0.028	0.572	<.001	36	view →
ESCA	DFS	Tertile	III,IV	0.769	0.291	.034	18	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RNU6-538P–LUSC (DFS)

Open the LUSC breakdown →