Across TCGA pan-cancer cohorts, RNU6-524P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-524P’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where RNU6-524P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-524P is over-expressed in tumor, although a few such as KICH and CHOL show the opposite, repressed pattern.
LUAD, KICH, and CHOL are the cancer types where RNU6-524P tumor–normal differential expression is most reproducible.