Across TCGA pan-cancer cohorts, RNU6-4P RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated RNU6-4P data layer.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNU6-4P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU6-4P expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.
HNSC, THCA, and UVM are the cancer types where RNU6-4P RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.