Across TCGA pan-cancer cohorts, RNU6-4P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-4P’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where RNU6-4P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-4P is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.
LUAD, LIHC, and STAD are the cancer types where RNU6-4P tumor–normal differential expression is most reproducible.