RNU6-494P

Across TCGA pan-cancer cohorts, RNU6-494P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-494P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU6-494P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-494P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and THCA are the cancer types where RNU6-494P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-494P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.155	.035	4	view →
BLCA	Male	All	+0.426	.038	2	view →
THCA	All	All	−0.129	.028	1	view →
KIRC	All	All	+0.081	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RNU6-494P–HNSC

Open the HNSC breakdown →