Across TCGA pan-cancer cohorts, RNU6-460P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-460P’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU6-460P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-460P is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KICH, and PAAD are the cancer types where RNU6-460P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-460P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.382	<.001	4	view →
KICH	Female	All	−0.563	<.001	3	view →
PAAD	Female	All	+1.424	.040	2	view →
THCA	Male	III,IV	−0.667	.027	1	view →
CHOL	All	All	+0.647	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RNU6-460P RNA expression & survival · all RNU6-460P data types