RNU6-415P

Across TCGA pan-cancer cohorts, RNU6-415P RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RNU6-415P’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RNU6-415P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-415P is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and THCA are the cancer types where RNU6-415P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-415P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.684	<.001	9	view →
COAD	Male	II,III,IV	−1.161	<.001	9	view →
THCA	Female	All	−0.808	<.001	9	view →
LUSC	Female	All	−1.766	<.001	8	view →
KIRP	Female	All	−0.970	<.001	7	view →
HNSC	Male	All	−0.893	<.001	7	view →
BRCA	All	III,IV	−1.190	<.001	6	view →
UCEC	All	All	−1.355	<.001	4	view →
BLCA	All	All	−0.646	.018	4	view →
KIRC	All	All	+0.364	<.001	4	view →
READ	All	All	−1.166	.003	3	view →
PAAD	All	All	−1.235	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RNU6-415P–LUAD

Open the LUAD breakdown →