Across TCGA pan-cancer cohorts, RNU6-3P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-3P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU6-3P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-3P is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, LUSC, and LUAD are the cancer types where RNU6-3P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-3P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.090	.020	4	view →
LUSC	All	II,III,IV	+0.192	.023	2	view →
LUAD	All	All	+0.340	.006	1	view →
COAD	All	III,IV	−0.186	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RNU6-3P RNA expression & survival · all RNU6-3P data types