Across TCGA pan-cancer cohorts, RNU6-396P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU6-396P’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU6-396P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-396P is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

LUSC and BRCA are the cancer types where RNU6-396P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-396P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	−0.163	.040	2	view →
BRCA	Female	All	+0.163	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: RNU6-396P RNA expression & survival · all RNU6-396P data types