RNU6-389P

Across TCGA patient cohorts, RNU6-389P mutation is significantly associated with the RNA expression of many other genes, with 1,294 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNU6-389P-associated genes across cancer lineages are MTATP6P21, RPL22P14, and HIRA. Each is linked with RNU6-389P in more than 1 cancer types. Because this analysis shows association rather than direction, both RNU6-389P-to-partner and partner-to-RNU6-389P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P21 grouped by RNU6-389P-low versus RNU6-389P-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNU6-389P→partner) and Y-score (partner→RNU6-389P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTATP6P21 →	+0.357	+6.333	<.001	<.001	3	2
LUSC	RPL22P14 →	+0.175	+4.561	<.001	.005	3	2
UCEC	HIRA →	+0.493	+3.839	.001	<.001	3	1
UCEC	SNU13 →	+0.343	+3.556	.002	.002	3	1
UCEC	MICALL1 →	+0.666	+3.716	<.001	<.001	3	1
UCEC	CCDC134 →	+0.630	+3.354	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,294 associations by consensus.

MTATP6P21 by RNU6-389P expression — LUAD

Explore this box plot interactively →