RNU6-389P

Across TCGA patient cohorts, RNU6-389P mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNU6-389P-associated genes across cancer lineages are PCNA, PDCD4, and EGFR. Each is linked with RNU6-389P in more than 1 cancer types. Because this analysis shows association rather than direction, both RNU6-389P-to-partner and partner-to-RNU6-389P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RNU6-389P-low versus RNU6-389P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNU6-389P→partner) and Y-score (partner→RNU6-389P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.317	+2.459	.002	.020	3	2
UCEC	PDCD4 →	-0.622	-2.459	.006	.020	3	2
UCEC	EGFR →	-0.221	-2.459	.004	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.465	-3.000	.032	.036	3	1
UCEC	p62 Lck ligand →	+0.352	+2.179	.025	.034	3	1
UCEC	Stathmin →	+0.174	+3.169	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PCNA by RNU6-389P expression — UCEC

Explore this box plot interactively →