RNU6-388P

Across TCGA pan-cancer cohorts, RNU6-388P RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RNU6-388P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU6-388P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-388P is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

HNSC, BRCA, and STAD are the cancer types where RNU6-388P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-388P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.803	.003	7	view →
BRCA	All	III,IV	−0.648	<.001	6	view →
STAD	All	All	+0.480	.004	4	view →
KIRC	All	All	+0.244	.006	3	view →
CHOL	Male	All	+1.288	<.001	2	view →
LUAD	Female	II,III,IV	−0.715	.017	2	view →
UCEC	All	All	−0.476	.026	2	view →
LIHC	Male	III,IV	+0.467	.031	2	view →
THCA	Male	III,IV	−0.625	.033	1	view →
LUSC	All	All	−0.272	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RNU6-388P–HNSC

Open the HNSC breakdown →