RNU6-377P

Across TCGA pan-cancer cohorts, RNU6-377P RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RNU6-377P’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RNU6-377P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-377P is over-expressed in tumor.

COAD, PAAD, and BRCA are the cancer types where RNU6-377P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-377P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.635	<.001	8	view →
PAAD	All	All	+0.707	.030	4	view →
BRCA	All	II,III,IV	+0.423	.001	4	view →
BLCA	All	All	+0.527	.023	3	view →
READ	All	III,IV	+0.710	<.001	2	view →
CHOL	All	All	+0.435	.021	1	view →
LIHC	All	All	+0.063	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

RNU6-377P–COAD

Open the COAD breakdown →