RNU6-346P

Across TCGA pan-cancer cohorts, RNU6-346P RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated RNU6-346P data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNU6-346P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU6-346P expression acts as an unfavorable survival marker, although some lineages such as BRCA and THCA show a favorable association.

HNSC, CHOL, and BRCA are the cancer types where RNU6-346P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.518	0.739	.002	39	view →
CHOL	OS	Tertile	II,III,IV	0.019	0.675	<.001	36	view →
BRCA	DFS	Tertile	All	0.981	0.941	.003	36	view →
KIRC	DFS	Tertile	II,III,IV	0.466	0.683	.040	24	view →
READ	DFS	Tertile	IV	0.217	0.657	.006	18	view →
UCEC	DFS	Tertile	IV	0.218	0.601	.015	18	view →
THCA	DFS	Tertile	All	0.983	0.923	.011	15	view →
CESC	OS	Tertile	II,III,IV	0.949	0.719	.031	12	view →
ESCA	DFS	Quartile	IV	0.826	0.309	.040	12	view →
SKCM	DFS	Quartile	IV	0.040	0.733	.008	11	view →
UVM	DFS	Quartile	II,III,IV	0.560	0.790	.021	11	view →
SARC	DFS	Quartile	All	0.739	0.576	.002	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

RNU6-346P–HNSC (OS)

Open the HNSC breakdown →