RNU6-346P

Across TCGA pan-cancer cohorts, RNU6-346P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-346P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU6-346P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-346P is over-expressed in tumor, although a few such as READ and PRAD show the opposite, repressed pattern.

HNSC, KIRP, and READ are the cancer types where RNU6-346P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-346P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.240	.012	6	view →
KIRP	All	All	+0.509	.001	3	view →
READ	All	III,IV	−0.625	.022	2	view →
PRAD	All	All	−0.410	.004	2	view →
KIRC	All	IV	−0.174	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RNU6-346P–HNSC

Open the HNSC breakdown →