RNU6-322P

Across TCGA pan-cancer cohorts, RNU6-322P RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RNU6-322P’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RNU6-322P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-322P is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and COAD are the cancer types where RNU6-322P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-322P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.200	<.001	8	view →
KIRP	Female	II,III,IV	−1.522	<.001	4	view →
COAD	All	All	−0.659	.010	4	view →
BRCA	Female	All	−0.382	.026	2	view →
LIHC	All	All	+0.301	.038	2	view →
CHOL	Female	All	+1.783	.046	1	view →
ESCA	Female	All	+0.940	.014	1	view →
KICH	All	All	−0.467	.036	1	view →
LUAD	All	All	−0.455	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RNU6-322P–THCA

Open the THCA breakdown →