Across TCGA pan-cancer cohorts, RNU6-251P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-251P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where RNU6-251P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-251P is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
KICH, KIRC, and LUSC are the cancer types where RNU6-251P tumor–normal differential expression is most reproducible.