RNU6-218P

Across TCGA pan-cancer cohorts, RNU6-218P RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RNU6-218P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU6-218P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-218P is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and LUAD are the cancer types where RNU6-218P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-218P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.240	.001	10	view →
BLCA	All	All	+0.458	.001	6	view →
LUAD	All	All	+0.276	.003	5	view →
LUSC	Male	All	+0.372	<.001	4	view →
THCA	All	II,III,IV	−0.185	.013	3	view →
KICH	Male	III,IV	−0.570	.030	2	view →
COAD	Female	All	+0.243	.026	2	view →
PRAD	All	All	+0.183	.010	2	view →
BRCA	Female	All	+0.110	.022	2	view →
CHOL	All	All	+0.460	.025	1	view →
LIHC	Male	All	+0.121	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RNU6-218P–HNSC

Open the HNSC breakdown →