Across TCGA pan-cancer cohorts, RNU6-216P RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RNU6-216P data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RNU6-216P RNA is associated with better overall survival. In most high-consensus cancer types, elevated RNU6-216P expression acts as an unfavorable survival marker, although some lineages such as SKCM and STAD show a favorable association.

SKCM, DLBC, and STAD are the cancer types where RNU6-216P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.479	0.289	.003	21	view →
DLBC	DFS	Median	All	0.578	0.931	.002	21	view →
STAD	OS	Quartile	IV	0.858	0.186	.002	19	view →
UVM	DFS	Quartile	III,IV	0.319	0.647	.018	16	view →
THCA	DFS	Quartile	II,III,IV	0.422	0.794	.007	16	view →
GBM	DFS	Median	All	0.207	0.284	.020	12	view →
LUSC	DFS	Median	II,III,IV	0.301	0.468	.017	12	view →
LGG	DFS	Median	All	0.788	0.873	.004	12	view →
CHOL	OS	Tertile	II,III,IV	0.934	0.501	.027	12	view →
KIRC	DFS	Median	III,IV	0.368	0.559	.024	11	view →
MESO	OS	Median	II,III,IV	0.467	0.327	.032	11	view →
LAML	DFS	Median	All	0.532	0.244	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same gene, other analysis: RNU6-216P tumor-vs-normal RNA expression · all RNU6-216P data types