Across TCGA pan-cancer cohorts, RNU6-216P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-216P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where RNU6-216P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-216P is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.
KICH, THCA, and KIRC are the cancer types where RNU6-216P tumor–normal differential expression is most reproducible.