RNU6-2

Across TCGA pan-cancer cohorts, RNU6-2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RNU6-2 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher RNU6-2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU6-2 expression acts as an unfavorable survival marker, although some lineages such as BLCA and ESCA show a favorable association.

MESO, BLCA, and KIRC are the cancer types where RNU6-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.282	0.483	.001	82	view →
BLCA	DFS	Tertile	All	0.462	0.097	<.001	51	view →
KIRC	DFS	Quartile	IV	0.198	0.623	<.001	45	view →
LIHC	OS	Tertile	All	0.708	0.852	<.001	37	view →
ESCA	OS	Quartile	III,IV	0.711	0.300	.002	34	view →
KICH	OS	Tertile	II,III,IV	0.489	0.937	.007	31	view →
UCS	DFS	Tertile	IV	0.237	0.784	.004	30	view →
HNSC	DFS	Quartile	IV	0.519	0.748	<.001	29	view →
COAD	OS	Tertile	II,III,IV	0.766	0.920	.001	27	view →
PAAD	OS	Quartile	All	0.693	0.342	.002	22	view →
ACC	OS	Quartile	II,III,IV	0.589	0.938	.018	16	view →
THYM	DFS	Quartile	III,IV	0.408	1.000	.012	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RNU6-2–MESO (OS)

Open the MESO breakdown →