RNU6-2

Across TCGA pan-cancer cohorts, RNU6-2 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RNU6-2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RNU6-2 RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and UCEC are the cancer types where RNU6-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−2.182	<.001	11	view →
LIHC	Male	All	+0.523	<.001	6	view →
UCEC	All	All	+0.687	.003	4	view →
CHOL	Male	All	+0.811	.002	2	view →
READ	All	III,IV	+0.685	<.001	2	view →
KICH	Female	II,III,IV	−0.521	.022	2	view →
LUSC	All	All	+0.399	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

RNU6-2–THCA

Open the THCA breakdown →