Across TCGA pan-cancer cohorts, RNU6-181P Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated RNU6-181P data layer compared with 18 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher RNU6-181P Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNU6-181P expression acts as an unfavorable survival marker.

ESCA and COAD are the cancer types where RNU6-181P Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.136	0.703	<.001	24	view →
COAD	DFS	Median	All	0.184	0.689	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: RNU6-181P tumor-vs-normal RNA expression · all RNU6-181P data types