RNU6-178P

Across TCGA pan-cancer cohorts, RNU6-178P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-178P’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RNU6-178P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-178P is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, PRAD, and CHOL are the cancer types where RNU6-178P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-178P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.394	<.001	9	view →
PRAD	All	All	+0.245	.014	2	view →
CHOL	All	All	+0.570	.029	1	view →
KICH	All	All	−0.207	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RNU6-178P–THCA

Open the THCA breakdown →