RNU6-176P

Across TCGA pan-cancer cohorts, RNU6-176P RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated RNU6-176P data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RNU6-176P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNU6-176P expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

KIRC, BLCA, and MESO are the cancer types where RNU6-176P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	II,III,IV	0.362	0.588	<.001	107	view →
BLCA	OS	Tertile	All	0.632	0.357	<.001	75	view →
MESO	OS	Tertile	All	0.052	0.528	.016	54	view →
SKCM	DFS	Tertile	All	0.068	0.242	.004	39	view →
LGG	DFS	Tertile	All	0.220	0.457	.003	36	view →
PCPG	OS	Tertile	All	0.505	0.946	<.001	30	view →
THCA	DFS	Tertile	II,III,IV	0.237	0.760	.014	18	view →
BRCA	DFS	Tertile	All	0.627	0.515	.027	12	view →
LIHC	DFS	Tertile	III,IV	0.094	0.424	.003	9	view →
DLBC	DFS	Median	IV	0.195	0.923	.038	5	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

RNU6-176P–KIRC (DFS)

Open the KIRC breakdown →