RNU6-176P

Across TCGA pan-cancer cohorts, RNU6-176P RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RNU6-176P’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU6-176P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-176P is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LIHC, and STAD are the cancer types where RNU6-176P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-176P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.194	.013	2	view →
LIHC	Male	All	+0.095	.021	2	view →
STAD	All	IV	+0.530	.042	1	view →
LUAD	Male	All	−0.363	.022	1	view →
HNSC	Male	IV	+0.235	.040	1	view →
KIRP	Male	All	+0.160	.039	1	view →
BRCA	All	All	−0.088	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

RNU6-176P–LUSC

Open the LUSC breakdown →