Across TCGA pan-cancer cohorts, RNU6-171P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU6-171P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNU6-171P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-171P is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC and KICH are the cancer types where RNU6-171P tumor–normal differential expression is most reproducible.