RNU6-123P

Across TCGA pan-cancer cohorts, RNU6-123P RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated RNU6-123P data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher RNU6-123P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNU6-123P expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

UVM, DLBC, and UCEC are the cancer types where RNU6-123P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.407	0.781	<.001	63	view →
DLBC	OS	Tertile	All	0.153	0.800	.006	48	view →
UCEC	DFS	Tertile	III,IV	0.682	0.819	.017	48	view →
BRCA	OS	Tertile	IV	0.420	0.827	.008	36	view →
ACC	DFS	Tertile	IV	0.048	0.411	.001	36	view →
LUSC	OS	Tertile	IV	0.057	0.786	.008	36	view →
THCA	OS	Tertile	IV	0.771	1.000	.010	27	view →
READ	DFS	Tertile	All	1.000	0.493	.022	18	view →
KIRC	DFS	Median	All	0.934	0.835	.001	17	view →
LIHC	OS	Tertile	III,IV	0.375	0.632	.030	9	view →
ESCA	OS	Tertile	All	0.449	1.000	.024	6	view →
OV	OS	Median	IV	0.867	0.635	.042	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

RNU6-123P–UVM (DFS)

Open the UVM breakdown →