RNU6-123P

Across TCGA pan-cancer cohorts, RNU6-123P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-123P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RNU6-123P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-123P is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KICH, LUSC, and KIRP are the cancer types where RNU6-123P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-123P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.350	.003	5	view →
LUSC	Female	II,III,IV	+0.547	.013	3	view →
KIRP	Male	All	+0.217	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

RNU6-123P–KICH

Open the KICH breakdown →