Across TCGA pan-cancer cohorts, RNU6-1217P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-1217P’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where RNU6-1217P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-1217P is over-expressed in tumor.
LUAD, LUSC, and KIRC are the cancer types where RNU6-1217P tumor–normal differential expression is most reproducible.