RNU6-100P

Across TCGA pan-cancer cohorts, RNU6-100P RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RNU6-100P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU6-100P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-100P is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, LIHC, and KIRC are the cancer types where RNU6-100P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-100P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.497	.003	8	view →
LIHC	All	All	+0.240	<.001	7	view →
KIRC	All	All	+0.321	.002	5	view →
CHOL	All	II,III,IV	+1.605	<.001	4	view →
STAD	All	II,III,IV	+0.738	.001	4	view →
BLCA	All	III,IV	+0.718	.009	4	view →
KICH	All	All	−0.392	.007	4	view →
LUAD	All	IV	−0.955	<.001	3	view →
PRAD	All	All	+0.284	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RNU6-100P–HNSC

Open the HNSC breakdown →