RNU5E-3P

Across TCGA pan-cancer cohorts, RNU5E-3P RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated RNU5E-3P data layer.

The strongest signal is observed in mesothelioma (MESO), where higher RNU5E-3P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU5E-3P expression acts as an unfavorable survival marker, although some lineages such as BLCA and STAD show a favorable association.

MESO, ESCA, and LUAD are the cancer types where RNU5E-3P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.069	0.580	<.001	108	view →
ESCA	OS	Tertile	IV	0.095	0.512	.008	36	view →
LUAD	DFS	Tertile	III,IV	0.117	0.651	<.001	36	view →
LGG	DFS	Tertile	All	0.407	0.736	.009	15	view →
BLCA	DFS	Tertile	All	0.502	0.332	<.001	12	view →
STAD	OS	Tertile	III,IV	0.751	0.403	.020	9	view →
THCA	DFS	Tertile	All	0.545	0.841	.005	9	view →
PCPG	DFS	Tertile	All	0.135	0.770	.044	9	view →
HNSC	OS	Tertile	All	0.907	0.353	.048	6	view →
PRAD	OS	Tertile	All	0.967	0.995	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

RNU5E-3P–MESO (OS)

Open the MESO breakdown →