Across TCGA pan-cancer cohorts, RNU5E-1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated RNU5E-1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher RNU5E-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU5E-1 expression acts as an unfavorable survival marker, although some lineages such as OV and UCS show a favorable association.

MESO, ESCA, and LIHC are the cancer types where RNU5E-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.399	0.680	<.001	93	view →
ESCA	OS	Median	II,III,IV	0.568	0.783	.002	66	view →
LIHC	DFS	Median	All	0.356	0.488	.001	61	view →
KICH	OS	Quartile	All	0.790	0.959	.002	45	view →
OV	OS	Median	IV	0.504	0.255	.001	36	view →
LGG	DFS	Median	All	0.345	0.462	.003	19	view →
ACC	OS	Tertile	All	0.611	0.917	.008	18	view →
SKCM	DFS	Median	IV	0.068	0.637	.007	15	view →
HNSC	DFS	Tertile	All	0.647	0.746	.015	13	view →
UCS	DFS	Median	All	0.647	0.384	.007	10	view →
SARC	DFS	Quartile	All	0.222	0.414	.004	10	view →
CHOL	DFS	Tertile	III,IV	1.000	0.182	.034	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

Exploration

Same gene, other analysis: RNU5E-1 tumor-vs-normal RNA expression · all RNU5E-1 data types