Across TCGA pan-cancer cohorts, RNU5D-1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU5D-1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RNU5D-1 RNA is repressed in tumor relative to normal tissue. In most cancer types RNU5D-1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and LUSC are the cancer types where RNU5D-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU5D-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−2.616	<.001	11	view →
BRCA	All	III,IV	−0.331	.026	2	view →
LUSC	All	All	−0.232	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNU5D-1 RNA expression & survival · all RNU5D-1 data types