RNU5B-3P

Across TCGA pan-cancer cohorts, RNU5B-3P RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RNU5B-3P’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU5B-3P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU5B-3P is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

LUSC, COAD, and READ are the cancer types where RNU5B-3P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU5B-3P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	−1.151	<.001	9	view →
COAD	All	All	−0.334	<.001	8	view →
READ	Male	All	−0.563	.001	7	view →
BRCA	All	III,IV	−1.528	<.001	6	view →
LUAD	Female	All	−0.931	<.001	6	view →
KIRC	Female	IV	−0.355	.013	6	view →
KIRP	All	All	−0.382	.001	5	view →
UCEC	All	All	−0.569	.002	2	view →
KICH	Male	All	−0.384	.005	2	view →
PRAD	All	All	−0.135	.042	2	view →
LIHC	All	All	+0.131	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RNU5B-3P–LUSC

Open the LUSC breakdown →