Across TCGA pan-cancer cohorts, RNU4ATAC2P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU4ATAC2P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where RNU4ATAC2P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU4ATAC2P is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.
KICH and LUAD are the cancer types where RNU4ATAC2P tumor–normal differential expression is most reproducible.