Across TCGA pan-cancer cohorts, RNU4-58P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU4-58P’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RNU4-58P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU4-58P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA and KIRC are the cancer types where RNU4-58P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU4-58P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.100	.028	1	view →
KIRC	All	All	+0.028	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: RNU4-58P RNA expression & survival · all RNU4-58P data types