RNU4-49P

Across TCGA pan-cancer cohorts, RNU4-49P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU4-49P’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where RNU4-49P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU4-49P is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

STAD, ESCA, and KIRP are the cancer types where RNU4-49P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU4-49P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.236	.003	5	view →
ESCA	All	II,III,IV	+0.365	.021	2	view →
KIRP	Male	All	−0.070	.037	2	view →
PRAD	All	All	+0.062	.026	2	view →
THCA	Female	All	−0.084	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RNU4-49P–STAD

Open the STAD breakdown →