Across TCGA pan-cancer cohorts, RNU4-21P RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RNU4-21P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RNU4-21P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU4-21P is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
THCA, STAD, and KICH are the cancer types where RNU4-21P tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU4-21P RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.