Across TCGA pan-cancer cohorts, RNU4-20P RNA is linked to patient survival in 4 of 34 cancer types, making it the most broadly survival-associated RNU4-20P data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNU4-20P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU4-20P expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

HNSC, UCEC, and STAD are the cancer types where RNU4-20P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.082	0.711	<.001	81	view →
UCEC	OS	Tertile	II,III,IV	0.204	0.768	.003	72	view →
STAD	OS	Tertile	All	0.142	0.735	<.001	63	view →
ESCA	OS	Tertile	III,IV	1.000	0.372	.033	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RNU4-20P tumor-vs-normal RNA expression · all RNU4-20P data types