Across TCGA pan-cancer cohorts, RNU4-14P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU4-14P’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RNU4-14P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU4-14P is over-expressed in tumor.
BLCA and LUAD are the cancer types where RNU4-14P tumor–normal differential expression is most reproducible.