RNU2-35P

Across TCGA pan-cancer cohorts, RNU2-35P RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RNU2-35P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU2-35P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU2-35P is over-expressed in tumor.

HNSC, LUSC, and COAD are the cancer types where RNU2-35P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU2-35P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.123	.004	7	view →
LUSC	All	All	+0.269	<.001	6	view →
COAD	Male	All	+0.255	.022	3	view →
UCEC	All	IV	+0.815	.026	2	view →
CHOL	All	II,III,IV	+0.590	<.001	2	view →
STAD	Male	II,III,IV	+0.170	.005	1	view →
LUAD	All	All	+0.113	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

RNU2-35P–HNSC

Open the HNSC breakdown →