Across TCGA pan-cancer cohorts, RNU2-28P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU2-28P’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where RNU2-28P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU2-28P is over-expressed in tumor, although a few such as BRCA and LUSC show the opposite, repressed pattern.

BRCA, LUSC, and THCA are the cancer types where RNU2-28P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU2-28P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.256	.001	6	view →
LUSC	All	II,III,IV	−0.252	<.001	6	view →
THCA	All	All	−0.243	<.001	2	view →
KICH	All	All	+0.226	.012	2	view →
CHOL	All	All	−0.226	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RNU2-28P RNA expression & survival · all RNU2-28P data types