RNU2-27P

Across TCGA pan-cancer cohorts, RNU2-27P RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RNU2-27P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNU2-27P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU2-27P is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where RNU2-27P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU2-27P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.177	<.001	11	view →
THCA	All	All	−0.555	<.001	7	view →
LUAD	Male	All	+0.752	<.001	6	view →
LUSC	Male	II,III,IV	+0.768	<.001	5	view →
LIHC	All	All	+0.545	<.001	5	view →
STAD	All	II,III,IV	+0.743	.007	3	view →
HNSC	All	III,IV	+0.578	.030	3	view →
BRCA	All	All	+0.217	.034	3	view →
CHOL	All	All	+1.551	.001	2	view →
UCEC	All	III,IV	+1.305	.044	2	view →
KIRP	Male	All	−0.833	<.001	2	view →
BLCA	All	IV	+0.889	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RNU2-27P–KIRC

Open the KIRC breakdown →