RNU11

Across TCGA pan-cancer cohorts, RNU11 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RNU11’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RNU11 RNA is repressed in tumor relative to normal tissue. In most cancer types RNU11 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BLCA are the cancer types where RNU11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−3.572	<.001	11	view →
KICH	All	All	−0.365	<.001	8	view →
BLCA	Female	III,IV	−0.648	.011	2	view →
PAAD	Female	All	−0.615	.038	2	view →
BRCA	All	III,IV	−0.433	.014	2	view →
LUAD	Female	II,III,IV	−0.437	.036	1	view →
KIRC	Male	IV	+0.305	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

RNU11–THCA

Open the THCA breakdown →