Across TCGA pan-cancer cohorts, RNU11-6P RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RNU11-6P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RNU11-6P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU11-6P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where RNU11-6P tumor–normal differential expression is most reproducible.