Across TCGA pan-cancer cohorts, RNU105B RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated RNU105B data layer.
The strongest signal is observed in cholangiocarcinoma (CHOL), where higher RNU105B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU105B expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.
CHOL, STAD, and KIRP are the cancer types where RNU105B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.