RNU1-6P

Across TCGA pan-cancer cohorts, RNU1-6P RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated RNU1-6P data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNU1-6P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU1-6P expression acts as an unfavorable survival marker, although some lineages such as ESCA and TGCT show a favorable association.

HNSC, THYM, and BRCA are the cancer types where RNU1-6P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.195	0.618	<.001	63	view →
THYM	DFS	Tertile	All	0.117	0.892	<.001	54	view →
BRCA	DFS	Tertile	IV	0.175	0.730	.005	36	view →
COAD	DFS	Tertile	III,IV	0.140	0.671	<.001	36	view →
LGG	OS	Tertile	All	0.405	0.803	<.001	27	view →
ESCA	OS	Tertile	III,IV	1.000	0.372	.032	18	view →
TGCT	DFS	Tertile	All	0.937	0.624	.028	18	view →
LUAD	DFS	Tertile	IV	0.382	0.739	.045	18	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.038	9	view →
LIHC	OS	Tertile	All	0.199	0.706	.047	9	view →
SARC	DFS	Tertile	All	0.874	0.309	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

RNU1-6P–HNSC (OS)

Open the HNSC breakdown →