Across TCGA patient cohorts, RNLS mutation is significantly associated with the RNA expression of many other genes, with 2,651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNLS-associated genes across cancer lineages are MTND4P33, MIR181A1, and RPS10P21. Each is linked with RNLS in more than 1 cancer types. Because this analysis shows association rather than direction, both RNLS-to-partner and partner-to-RNLS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNLS→partner) and Y-score (partner→RNLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTND4P33 →	+0.028	+4.408	<.001	.005	3	2
LUAD	MIR181A1 →	+0.545	+5.343	.001	.006	3	2
HNSC	RPS10P21 →	+0.194	+4.780	<.001	.003	3	2
HNSC	H2BP8 →	+0.105	+4.578	<.001	.008	3	2
HNSC	RNU7-10P →	+0.913	+5.266	<.001	.001	3	2
UCEC	NPAS2 →	-0.841	-2.652	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,651 associations by consensus.

Exploration

RNLS survival (RNA) · tumor vs normal (RNA) · all RNLS data types